| Pair Name | Glabridin, Paclitaxel | ||
| Phytochemical Name | Glabridin (PubChem CID: 124052 ) | ||
| Anticancer drug Name | Paclitaxel (PubChem CID: 36314 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Glabridin, Paclitaxel | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Inhibition-->Cell migration | |||
| Gene Regulation | Up-regulation | Cleavage | CASP9 | hsa842 |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | VIM | hsa7431 | |
| Up-regulation | Expression | CDH1 | hsa999 | |
| Down-regulation | Expression | ZEB1 | hsa6935 | |
| Up-regulation | Expression | OCLN | hsa100506658 | |
| Down-regulation | Expression | CYP2C8 | hsa1558 | |
| Down-regulation | Expression | CYP2J2 | hsa1573 | |
| In Vitro Model | 4T1 | Malignant neoplasms of the mouse mammary gland | Mus musculus (Mouse) | CVCL_0125 |
| In Vivo Model | The effect of glabridin on the pharmacokinetics of paclitaxel was assessed in healthy female Balb/C mice (25–30 g of body weight). | |||
| Result | Glabridin plays dual action to intensify anti-metastatic potential of paclitaxel via impeding CYP2C8 in liver and CYP2J2/EETs in tumor of an orthotopic mouse model of breast cancer | |||
| No. | Title | Href |
|---|---|---|
| 1 | Glabridin plays dual action to intensify anti-metastatic potential of paclitaxel via impeding CYP2C8 in liver and CYP2J2/EETs in tumor of an orthotopic mouse model of breast cancer. Chem Biol Interact. 2023 Sep 1;382:110605. doi: 10.1016/j.cbi.2023.110605. | Click |
